AB Kader
Treatment
Prophylaxis
Antibiotics in dental care
Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Antibiotics in dental care
Principles · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Principles
Dental professionals · adults
An odontogenic infection with spread or systemic red flags may require antibiotics in addition to source control. Adjunctive treatment may also be considered in selected cases of severe or rapidly progressing periodontitis.
Prophylaxis aims to prevent a complication around a procedure. There are separate indications in implantology and for patients with endocarditis risk, MRONJ risk or certain oncology-related circumstances. A single prophylactic dose is not a treatment course.
Diagnose and treat the local cause. Discuss the expected benefits, adverse effects and risk of resistance. Choose an antibiotic with a spectrum appropriate to the indication.
Check previous allergic reactions, recent antibiotic use, comorbidities, renal and hepatic function, and the current medication list. Follow the protocol for the risk group and consult the treating specialist if needed. If the extent of an odontogenic infection is uncertain, consult or refer to an oral and maxillofacial surgeon.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · richtlijntekst 3 maart 2025
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/algemene-principes-van-rationeel-antibioticumgebruik/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 4
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-parodontitis/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 1
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/uitgangsvraag-1/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 8
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/preventie-van-mronj-patienten-met-botafbraakremmende-medicatie-of-angiogeneseremmers/
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
KIMO — Kennisinstituut Mondzorg · In werking 15 juni 2026 · PDF-tekst 28 maart 2025 · KNMT-aanvaarding 20 april 2026
https://www.hetkimo.nl/wp-content/uploads/2026/06/KPR-EMK-richtlijn-28032025.pdf
Antibiotics in dental care
Odontogenic infection or abscess · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Adults with an odontogenic infection or abscess
Antibiotics are generally not indicated for a localised infection or abscess. Treat the local cause and drain the abscess if its location and margins allow.
Consider adjunctive antibiotics for a spreading infiltrate or red flags after assessing severity and the need for referral.
If antibiotic treatment is chosen: amoxicillin 500 mg by mouth three times daily for five days if the clinical response is good. For amoxicillin allergy, KIMO lists clindamycin 600 mg by mouth three times daily for five days.
Assess the clinical course after source control. If the response is inadequate, reassess the diagnosis, source control and need for referral before changing or renewing the course.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
Nederlandse Vereniging voor Mond-, Kaak- en Aangezichtschirurgie · 2024 · Bijlage 5
https://www.nvmka.nl/wp-content/uploads/2024-Bijlage_Spoedlijst_5__NVMKA_Nederlandse_Vereniging_voor_Mond-_Kaak-_en_Aangezichtschirurgie.pdf
Antibiotics in dental care
Apical periodontitis · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Adults with periapical granuloma or apical periodontitis
Routine antibiotics are not indicated for a periapical granuloma or apical periodontitis. Provide endodontic treatment or retreatment, with apical surgery if needed. Extraction is an alternative.
If infection is spreading or there are systemic signs, see “Odontogenic infection or abscess”.
Antibiotics are not indicated for pain from irreversible pulpitis. Treat the pulp locally and provide appropriate pain relief. If there are signs of spreading or systemic infection, follow the guidance for odontogenic infection.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 6
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-periapicaal-granuloom-parodontitis-apicalis/
Nederlandse Vereniging voor Endodontologie · Update 2025 · versie 1.0
https://nvve.com/wp-content/uploads/2026/08/Richtlijn-Endodontische-Diagnostiek-en-Behandeling-update-2025_v1.0.pdf#page=221
Antibiotics in dental care
Periodontitis and necrotising conditions · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Adults · antibiotics only as an adjunct to periodontal treatment
Consider adjunctive antibiotics for generalised advanced to very advanced rapidly progressing periodontitis with relatively little plaque and calculus, documented rapid bone loss, or necrotising periodontal disease with systemic symptoms.
This is not routine treatment. It requires comprehensive supra- and subgingival treatment, professional cleaning, good motivation and self-care, and discussion of the benefits and risks.
When antibiotics are indicated, the preferred monotherapy is metronidazole 500 mg by mouth three times daily for seven days.
Consider combining amoxicillin with metronidazole when well-delivered periodontal treatment gives an inadequate response despite good self-care, or in adults aged 18 to 20 years with a molar–incisor pattern. KIMO gives 500 mg amoxicillin and 500 mg metronidazole, each three times daily for seven days, as an example.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 4
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-parodontitis/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/m/metronidazol__oraal_
Antibiotics in dental care
Peri-implantitis and mucositis · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Adults with peri-implant inflammation
Start with mechanical cleaning and oral hygiene instruction for peri-implant mucositis and peri-implantitis. In mucositis, antibiotics provide no additional benefit over mechanical cleaning.
No added benefit has been established for systemic antibiotics with surgical or non-surgical treatment of peri-implantitis. If antibiotics are considered, take into account microbiology, resistance, disease severity and immune status. Arrange surgical follow-up if the response is inadequate.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 5 · verwijsmodule
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-peri-implantitis/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2018 · richtlijnsamenvatting 4 en 5
https://www.hetkimo.nl/richtlijnen/peri-implantaire-mucositis-en-peri-implantitis/introductie/
Antibiotics in dental care
Implantology and bone augmentation · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults · general implant indication. Separate risk protocols still apply
Discuss prophylaxis for bone augmentation, with or without implant placement, including sinus floor elevation, guided bone regeneration and immediate implant placement. Previous implant failure, limited options if a new implant fails, or an increased risk of impaired wound healing, such as with diabetes, may also warrant consideration.
Be cautious about prophylaxis for uncomplicated implant placement without additional risk factors or augmentation, soft tissue surgery, and ridge preservation using only a bone substitute. Discuss the expected benefits and harms.
If prophylaxis is chosen, give a single dose of amoxicillin 2 g by mouth 30 to 60 minutes before the procedure. For amoxicillin allergy, KIMO lists a single dose of clindamycin 600 mg by mouth.
Extended prophylaxis is not indicated. For unusually long procedures, consult the perioperative protocol.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 1
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/uitgangsvraag-1/
Antibiotics in dental care
Endodontic treatment · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults undergoing endodontic surgery, including apical surgery
Restrict prophylaxis for endodontic procedures. Consider it only where there is a real risk of infectious complications.
This general recommendation does not apply to an existing infection or abscess and does not specify a universal regimen. Assess separately whether endocarditis or MRONJ prophylaxis is needed.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 2
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/antibioticaprofylaxe-endodontologie/
Antibiotics in dental care
Third molar removal · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults · surgical removal of third molar
Do not give antibiotics routinely around third molar removal. A higher risk of postoperative complications or a separate indication for prophylaxis may justify an exception.
KIMO 2025 refers to the aftercare module of the 2020 third molar guideline, which gives no general recommendation for the drug, dose or duration. Assess any indication for endocarditis or MRONJ prophylaxis separately.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 3 · verwijsmodule
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/antibioticaprofylaxe-derde-molaar/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2020 · §5.1 Antibiotica
https://www.hetkimo.nl/richtlijnen/derde-molaar/nazorg/
Antibiotics in dental care
Endocarditis prophylaxis · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults · high-risk patient and relevant dental procedure
Prophylaxis is for a high-risk patient undergoing a relevant procedure. The NVVC lists previous endocarditis, a prosthetic valve, a ventricular assist device and congenital heart disease such as unrepaired cyanotic defects or palliative shunts, conduits and other prostheses. The NHG also specifies repair of an ASD, VSD or patent ductus arteriosus using prosthetic material through six months after repair, and a residual shunt that may impair endothelialisation. Confirm the precise cardiac diagnosis and current specialist plan.
The NHG lists gingival manipulation, endodontic instrumentation beyond the apical foramen, extraction or root removal, and oral surgery, including abscess incision, periodontal surgery and implant surgery. Local anaesthesia, intraoral radiographs and routine work on orthodontic appliances are not indications in themselves.
For adults, the NVVC recommends amoxicillin 2 g by mouth as first choice and clindamycin 600 mg by mouth for confirmed penicillin or ampicillin allergy. The NHG treatment guideline specifies a single oral dose 30 to 60 minutes before the procedure. It also lists clindamycin if penicillin has been used in the previous seven days. If penicillin was used during that period, agree the choice of medicine with the cardiology team.
The NVVC lists ceftriaxone 1 g intravenously as an alternative. It requires a separate specialist and allergy assessment and appropriate administration. Do not substitute it automatically in severe beta-lactam allergy.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Nederlands Huisartsen Genootschap · auteursversie via NVMKA · Versie 1.0 · november 2016 · oorspronkelijke tekst; huidige NHG-webrevisie niet verifieerbaar
https://www.nvmka.nl/wp-content/uploads/2022/07/2016-NHG-Behandelrichtlijn-Endocarditisprofylaxe-1.pdf
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/ceftriaxon
European Society of Cardiology · ESC 2023 · Essential messages
https://www.escardio.org/static-file/Escardio/Guidelines/Products/Slide%20sets/2023%20Gls/Essential%20Messages_2023%20Endocarditis.pdf
Antibiotics in dental care
MRONJ risk and bone medication · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults with current or previous use of antiresorptive medicines or angiogenesis inhibitors
Ask about medicines used previously as well. Antibiotic prophylaxis is not indicated for endodontic or periodontal treatment without bone manipulation.
For extraction, implant or periodontal procedures involving bone manipulation, and apical surgery, KIMO advises against prophylaxis after less than 24 months of oral antiresorptive treatment or less than one year of intravenous antiresorptive treatment. Prophylaxis is indicated after 24 to 36 months of oral treatment.
Use extreme caution if the patient has taken oral antiresorptives for at least 36 months, received intravenous antiresorptives for at least one year or uses angiogenesis inhibitors. If the procedure is unavoidable, treatment in secondary care with prophylaxis is preferred.
When prophylaxis is indicated, KIMO lists amoxicillin as the preferred agent and clindamycin for amoxicillin allergy. There is no consensus on the dose. Document the medicine, dose, timing and duration in the individual treatment plan.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 8
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/preventie-van-mronj-patienten-met-botafbraakremmende-medicatie-of-angiogeneseremmers/
KIMO — Kennisinstituut Mondzorg · In werking 15 juni 2026 · PDF-tekst 28 maart 2025 · KNMT-aanvaarding 20 april 2026
https://www.hetkimo.nl/wp-content/uploads/2026/06/KPR-EMK-richtlijn-28032025.pdf
Antibiotics in dental care
Cancer treatment and immune function · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
Adults · cancer-related myelosuppression or previous head and neck radiotherapy
Where possible, defer elective treatment until blood counts have recovered sufficiently. For urgent extractions or oral surgery during or after myelosuppressive cancer treatment, KIMO lists antibiotic prophylaxis for a neutrophil count below 1.5 × 10⁹/L, in consultation with the medical oncologist or haematologist.
A neutrophil count of 1.5 × 10⁹/L or higher does not indicate prophylaxis on this basis. A central line alone is also insufficient. Assess additional risk factors and the required treatment setting. The guideline gives no universal choice of antibiotic, dose or duration here.
If bone manipulation is planned in an area that received at least 25 Gy, consult an oral and maxillofacial surgeon or special dental care centre beforehand, preferably at a head and neck oncology centre. This also applies to urgent procedures and regardless of the time since radiotherapy. The need for consultation does not itself indicate antibiotic use.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 2
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/antibioticaprofylaxe-endodontologie/
KIMO — Kennisinstituut Mondzorg · In werking 15 juni 2026 · PDF-tekst 28 maart 2025 · KNMT-aanvaarding 20 april 2026
https://www.hetkimo.nl/wp-content/uploads/2026/06/KPR-EMK-richtlijn-28032025.pdf
Antibiotics in dental care
Amoxicillin · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Use the indication to guide safe medicine selection. See the relevant indication and medicine information.
KIMO lists amoxicillin for odontogenic infection when antibiotics are indicated and for selected implant prophylaxis. In complex periodontitis it may be considered together with metronidazole. Dutch guidance also lists a dose of oral amoxicillin for endocarditis prophylaxis. Dose and duration vary by indication.
If MRONJ prophylaxis is indicated, KIMO lists amoxicillin as the preferred agent. There is no consensus on the dose.
Do not use in penicillin hypersensitivity or after a severe reaction to another beta-lactam antibiotic. The FK also lists infectious mononucleosis and lymphocytic leukaemia as contraindications.
Check renal function and interactions, including those with vitamin K antagonists, methotrexate, allopurinol and probenecid. Consult the full monograph for dose adjustment, pregnancy, breastfeeding and excipients.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 4
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-parodontitis/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 1
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/uitgangsvraag-1/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 8
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/preventie-van-mronj-patienten-met-botafbraakremmende-medicatie-of-angiogeneseremmers/
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Antibiotics in dental care
Clindamycin · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
This is a specialist option for systemic treatment in adults. It is not an automatic substitute in patients with a penicillin allergy.
KIMO lists clindamycin for patients allergic to amoxicillin with odontogenic infections and for selected indications for implant prophylaxis or MRONJ prophylaxis. For adult endocarditis prophylaxis, the NVVC retains clindamycin for confirmed penicillin allergy. The 2023 ESC guideline removed clindamycin for this indication. Dose, frequency and duration depend on the indication. There is no consensus on dosing for MRONJ prophylaxis.
Lincomycin hypersensitivity is a contraindication. Check for a history of colitis, renal and hepatic impairment, and neuromuscular disorders. Clindamycin can also cause severe reactions in patients with penicillin allergy.
Do not combine with erythromycin. For vitamin K antagonists, monitor PT/INR. Check for other interactions, including with neuromuscular blockers, CYP3A4 inhibitors or inducers, and ciclosporin. Consult the full FK monograph, including its advice on pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 1
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/uitgangsvraag-1/
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 8
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/preventie-van-mronj-patienten-met-botafbraakremmende-medicatie-of-angiogeneseremmers/
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Antibiotics in dental care
Metronidazole · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Adults · Oral use
When adjunctive antibiotics are indicated in selected cases of periodontitis, KIMO prefers metronidazole alone: 500 mg by mouth three times daily for seven days. The combination with amoxicillin is reserved for selected complex cases.
Do not use in nitroimidazole hypersensitivity. Check in particular for interactions with vitamin K antagonists, lithium, disulfiram and ciclosporin. The FK also lists interactions with busulfan and fluoropyrimidines. Assess further if the patient has hepatic impairment or a neurological disorder.
The manufacturer advises avoiding alcohol, including alcohol-containing medicines, during treatment and for at least 48 hours after the last dose. Consult the full monograph for renal and hepatic function, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 4
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-parodontitis/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/m/metronidazol__oraal_
Antibiotics in dental care
Amoxicillin/clavulanic acid · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Adults · reserved option. Do not routinely broaden antibiotic cover
The FK lists spreading cellulitis with severe dental abscess as an indication. It advises reserving this combination for pathogens resistant to amoxicillin because they produce beta-lactamases that are susceptible to inhibition by clavulanic acid.
This combination is not a routine choice for odontogenic infections. If treatment has no effect, reassess source control and severity before changing treatment. Agree on broader treatment or specialist management if needed.
Do not use in severe penicillin or cephalosporin hypersensitivity, or in patients who previously had jaundice, hepatic impairment or AGEP caused by this combination. Check renal function and product strength. Avoid use if infectious mononucleosis is suspected or confirmed.
Check for interactions with methotrexate, vitamin K antagonists, mycophenolate, allopurinol and probenecid, among others. Consult the FK monograph for the full interactions list, dosing, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline_clavulaanzuur
College ter Beoordeling van Geneesmiddelen · RVG 09840
https://www.geneesmiddeleninformatiebank.nl/smpc/h09840_smpc.pdf
Antibiotics in dental care
Ceftriaxone · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Adults · specialist intravenous option for endocarditis prophylaxis
The NVVC lists ceftriaxone 1 g intravenously as an alternative regimen for endocarditis prophylaxis in high-risk dental procedures.
Assess the indication, hypersensitivity risk and route of administration separately. For penicillin allergy, use ceftriaxone only after that assessment. Section 4.1 of this SmPC does not list dental endocarditis prophylaxis as an indication.
Do not use in patients with cephalosporin hypersensitivity or a previous severe reaction to other beta-lactam antibiotics. Check the full FK monograph for combined hepatic and renal impairment, interactions, pregnancy, breastfeeding and administration.
Do not administer at the same time as intravenous calcium-containing solutions because of precipitation risk. For sequential administration in adults, follow the specified infusion-line precautions.
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/ceftriaxon
College ter Beoordeling van Geneesmiddelen · RVG 134134 · 1 g, poeder voor oplossing voor injectie/infusie
https://www.geneesmiddeleninformatiebank.nl/smpc/h134135_smpc.pdf
Antibiotics in dental care
Paediatric antibiotics · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Children
Children younger than 18 years. The selected regimen specifies the age limits and any weight limit for the calculation.
Treat the local cause in pulpitis or a localised abscess without spread or systemic signs. Consider systemic antibiotics only if the infection is spreading or systemic signs justify them.
Assess the cause and arrange drainage or other definitive treatment. Consult an oral and maxillofacial surgeon or paediatrician if the severity or suitability of oral treatment is uncertain.
This regimen applies to non-severe odontogenic infection for which oral antibiotics are indicated. For paediatric dosing, KIMO refers to the Kinderformularium. The product information gives a wider dose range for dental abscess with spreading cellulitis.
For non-severe bacterial infections, the Kinderformularium lists oral amoxicillin at 50 mg/kg/day in three divided doses, up to 1,500 mg/day.
The calculator for odontogenic infection is available from 3 months of age and for a weight below 40 kg. Assess management individually in severe infection, penicillin allergy or when a dose adjustment is needed. The EAPD guidance describes reassessment after two to three days and treatment for up to five days, depending on source control and clinical recovery.
Confirm both a high-risk cardiac condition and a high-risk dental procedure. Follow the current cardiology plan. Amoxicillin is the usual first choice when oral prophylaxis is appropriate.
The Kinderformularium lists a single oral dose of 50 mg/kg amoxicillin, up to 2 g, 30 to 60 minutes before the procedure.
For confirmed penicillin allergy, the EAPD lists azithromycin or clarithromycin as an oral alternative. Use either only after the paediatric cardiologist confirms the indication and choice of medicine. Give a single dose of 15 mg/kg, up to 500 mg according to the ESC, 30 to 60 minutes before the procedure. This use is off-label for both medicines. Assess QT risk and check current medicines for interactions.
The Kinderformularium lists a single oral clindamycin dose of 20 mg/kg, up to 600 mg, 30 to 60 minutes before the procedure. The NVVC recommendation for clindamycin applies to adults. The older NHG treatment guideline uses different weight bands. Agree the choice and dose with the cardiology team in line with the current plan, including after recent penicillin use.
Use a recently measured body weight in kg. Before prescribing, check the indication, age, allergies, renal and hepatic function, and interactions. The calculator checks for outlying age and weight values. If weight remains outside the check limits after remeasurement, arrange an individual dose assessment.
Check the suspension concentration, dose in mg and volume in mL per dose. Compare the calculated dose with the maximum for the chosen regimen and confirm the volume can be measured accurately. Check the draft prescription before transferring it to the prescribing system.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Nederlands Huisartsen Genootschap · auteursversie via NVMKA · Versie 1.0 · november 2016 · oorspronkelijke tekst; huidige NHG-webrevisie niet verifieerbaar
https://www.nvmka.nl/wp-content/uploads/2022/07/2016-NHG-Behandelrichtlijn-Endocarditisprofylaxe-1.pdf
European Academy of Paediatric Dentistry · 2025 · Eur Arch Paediatr Dent 26:1037–1043
https://link.springer.com/article/10.1007/s40368-025-01068-9
Nederlands Kenniscentrum Farmacotherapie bij Kinderen · Online monografie
https://www.kinderformularium.nl/geneesmiddel/7/amoxicilline
Nederlands Kenniscentrum Farmacotherapie bij Kinderen · Online monografie
https://www.kinderformularium.nl/geneesmiddel/312/clindamycine
College ter Beoordeling van Geneesmiddelen · RVG 117001 · 125 mg/5 mL en RVG 117002 · 250 mg/5 mL
https://www.geneesmiddeleninformatiebank.nl/smpc/h117003_smpc.pdf
College ter Beoordeling van Geneesmiddelen · RVG 06354 · 75 mg/5 mL
https://www.geneesmiddeleninformatiebank.nl/smpc/h06354_smpc.pdf
American Academy of Pediatrics · Pediatrics 135(4):784–787 · 2015
https://publications.aap.org/pediatrics/article/135/4/e20150072/33600/Metric-Units-and-the-Preferred-Dosing-of-Orally
KNMG en beroepsorganisaties, waaronder KNMT · 2013 · Richtlijn Elektronisch voorschrijven
https://www.knmg.nl/download/richtlijn-elektronisch-voorschrijven-2
Centers for Disease Control and Prevention · CDC 2000 · documentatie 2024
https://www.cdc.gov/growth-chart-training/hcp/computer-programs/sas.html
Johnson KB et al. · Pediatrics · 2011 · 128(2):e422–e428
https://pmc.ncbi.nlm.nih.gov/articles/PMC3387858/
European Society of Cardiology · 2023 · European Heart Journal 44:3948–4042 · tabel 6
https://academic.oup.com/eurheartj/article/44/39/3948/7243107
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 14999
https://www.geneesmiddeleninformatiebank.nl/smpc/h14999_smpc.pdf
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 30849–30850
https://www.geneesmiddeleninformatiebank.nl/smpc/h30849_smpc.pdf
Antibiotics in dental care
Acute pericoronitis · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Assess pain and swelling around a partially erupted tooth, usually a lower third molar. Inspect the operculum and check whether the opposing tooth is traumatising it. Assess mouth opening, spread of swelling and systemic symptoms.
Clean and irrigate the space under the operculum where accessible. Remove trapped debris and provide pain relief if needed. After the acute phase, assess whether the affected tooth can erupt or whether the tooth or the traumatising opposing tooth needs removal.
The NVMKA advises against surgical extraction in the acute phase. Simple extraction without bone removal may be considered if mouth opening is sufficient and anaesthesia adequate. In pseudopericoronitis caused by traumatic contact, the NVMKA recommends treating the offending opposing tooth during the acute phase.
Inflammation confined to the operculum requires local treatment. Consider systemic antibiotics as an adjunct if there is general malaise or impending spread to a fascial space. If symptoms worsen or fail to improve, reassess for spread and consult an oral and maxillofacial surgeon if in doubt.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Health Service Executive, Ierland · Versie 2.0 · lokale behandeling
https://assets.hse.ie/media/documents/Pericoronitis_guideline.pdf#page=1
Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie · MKA-leidraad 1.3 · november 2025
https://www.nvmka.nl/wp-content/uploads/2025-Pericoronitis-MKA-leidraad-1.3.pdf
Antibiotics in dental care
Dry socket after extraction · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
Consider dry socket if pain worsens one to three days after extraction and the socket has lost part or all of the clot. Bad breath can occur. Pain can be severe when the clot is completely absent.
Diagnosis is based on the clinical course and inspection of the socket. Take a radiograph if a retained root is suspected.
Consider gently irrigating the socket with lukewarm water or saline. Explain how to rinse locally at home and advise appropriate analgesia. If there is insufficient improvement, a temporary dressing may be considered after reassessment. Agree when it will be removed.
Pain can persist for several days despite these measures. Tell the patient when to contact the practice, especially if symptoms worsen or new swelling or fever develops.
Antibiotics are not indicated for dry socket without concurrent infection. The NVMKA found no evidence of a therapeutic benefit.
If pus, increasing swelling or fever occurs, assess for postoperative wound infection and determine whether local source control is needed. If infection is spreading or systemic signs are present, follow the guidance for odontogenic infection and assess urgency.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie · MKA-leidraad 2.0 · november 2025
https://www.nvmka.nl/wp-content/uploads/2025-Alveolitis-MKA-leidraad-2.0.pdf
Antibiotics in dental care
Joint prosthesis · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Prophylaxis
A joint prosthesis, such as a hip or knee replacement, does not indicate antibiotics before a dental procedure to prevent haematogenous prosthetic joint infection. The NOV and KNMT state that this also applies to patients with impaired immunity.
Assess any separate indication, such as endocarditis prophylaxis, against the relevant guideline. Advise good oral hygiene and regular dental check-ups.
Nederlandse Orthopaedische Vereniging en Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde · Richtlijnmodule · 2016
https://richtlijnendatabase.nl/richtlijn/antibioticaprofylaxe_bij_gewrichtsprothese/antibioticaprofylaxe_bij_gewrichtsprothese.html
Antibiotics in dental care
Tooth injury: avulsion and replantation · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Treatment
In avulsion, the tooth is completely displaced from its socket. Arrange immediate dental care. The KNMT aims for assessment within 30 to 60 minutes. Check whether the tooth is permanent or primary. Do not replant a primary tooth.
Hold a permanent tooth by the crown only. If visibly contaminated, rinse it briefly and gently without touching or scrubbing the root. Replant as soon as possible if safe and feasible. If immediate replantation is not possible, keep the tooth in milk for transport.
Record the time out of the mouth, the time the tooth was dry and the storage medium. Assess root development, the socket and any associated injuries. After replantation, confirm the tooth's position clinically and radiographically.
The Dutch splinting instructions usually advise a flexible splint for three weeks after avulsion. Adapt the splinting plan if there is additional alveolar injury. Plan clinical and radiographic follow-up, and decide on endodontic management based on root development and healing.
Assess contamination of the tooth and wound. KIMO notes that the Dutch Dental Trauma Guide reserves immediate systemic antibiotics for signs of contamination. Follow the injury-specific protocol for the indication and choice of medicine.
Check tetanus vaccination status. If in doubt, consult the doctor about the tetanus prophylaxis required.
KIMO – Kennisinstituut Mondzorg · Nederlandse uitgave · 2025
https://www.hetkimo.nl/richtlijnen/dtg/over-de-dental-trauma-guide/
Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde · Online praktijkrichtlijn
https://knmt.nl/praktijkzaken/regelen-rond-kwaliteit-en-klachten/opvang-tandheelkundige-spoedgevallen/beoordeling-van-spoed
KNMT · Alles over het gebit · Online instructie voor eerste hulp bij tandletsel
https://www.allesoverhetgebit.nl/alles-over-mondgezondheid/aandoeningen/tand-eruit-tand-erin
KIMO – Kennisinstituut Mondzorg · Nederlandse instructie · 2025
https://www.hetkimo.nl/wp-content/uploads/2025/04/Spalkinstructie-KIMO-v2.pdf#page=3
International Association of Dental Traumatology · Dental Traumatology · 2020 · onderzoek, follow-up en tetanus
https://www.aapd.org/globalassets/media/policies_guidelines/e_avulsion.pdf
Antibiotics in dental care
Azithromycin · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Azithromycin is a macrolide. The EAPD lists it as an alternative for confirmed penicillin allergy when a child with a high-risk cardiac condition undergoes a high-risk dental procedure. Use it only after consulting the paediatric cardiologist. Its use for endocarditis prophylaxis is off-label.
The EAPD regimen is a single oral dose of 15 mg/kg, 30 to 60 minutes before the procedure. The ESC sets a maximum of 500 mg per dose. See Paediatric antibiotics for indications and other prophylactic regimens.
The calculator uses 200 mg/5 mL (40 mg/mL) from 6 months of age and for weights below 45 kg. At 45 kg or above, have the paediatric cardiologist and pharmacist confirm the formulation and dose.
Assess QT prolongation, electrolyte disturbances and concomitant medicines that prolong the QT interval. Seek individual assessment if there is significant hepatic or renal impairment.
European Academy of Paediatric Dentistry · 2025 · Eur Arch Paediatr Dent 26:1037–1043
https://link.springer.com/article/10.1007/s40368-025-01068-9
European Society of Cardiology · 2023 · European Heart Journal 44:3948–4042 · tabel 6
https://academic.oup.com/eurheartj/article/44/39/3948/7243107
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 14999
https://www.geneesmiddeleninformatiebank.nl/smpc/h14999_smpc.pdf
Antibiotics in dental care
Clarithromycin · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Medicine information
Clarithromycin is a macrolide. The EAPD lists it as an alternative for confirmed penicillin allergy when a child with a high-risk cardiac condition undergoes a high-risk dental procedure. Use it only after consulting the paediatric cardiologist. Its use for endocarditis prophylaxis is off-label.
The EAPD regimen is a single oral dose of 15 mg/kg, 30 to 60 minutes before the procedure. The ESC sets a maximum of 500 mg per dose. See Paediatric antibiotics for indications and other prophylactic regimens.
The calculator uses the 125 mg/5 mL (25 mg/mL) suspension from 6 months of age. Check the strength: the 250 mg/5 mL suspension requires a different volume.
Clarithromycin is contraindicated with known QT prolongation, previous ventricular arrhythmia, hypokalaemia or hypomagnesaemia. Check for CYP3A4 interactions, including with oral midazolam and ivabradine. Seek individual assessment if there is significant renal or hepatic impairment.
European Academy of Paediatric Dentistry · 2025 · Eur Arch Paediatr Dent 26:1037–1043
https://link.springer.com/article/10.1007/s40368-025-01068-9
European Society of Cardiology · 2023 · European Heart Journal 44:3948–4042 · tabel 6
https://academic.oup.com/eurheartj/article/44/39/3948/7243107
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 30849–30850
https://www.geneesmiddeleninformatiebank.nl/smpc/h30849_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · richtlijntekst 3 maart 2025
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/algemene-principes-van-rationeel-antibioticumgebruik/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 7
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/dentogene-infecties-en-of-abces/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 6
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-periapicaal-granuloom-parodontitis-apicalis/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 2
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/antibioticaprofylaxe-endodontologie/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/clindamycine__systemisch_
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 4
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-parodontitis/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 1
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/uitgangsvraag-1/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 8
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/preventie-van-mronj-patienten-met-botafbraakremmende-medicatie-of-angiogeneseremmers/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 3 · verwijsmodule
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/antibioticaprofylaxe-derde-molaar/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2020 · §5.1 Antibiotica
https://www.hetkimo.nl/richtlijnen/derde-molaar/nazorg/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2025 · uitgangsvraag 5 · verwijsmodule
https://www.hetkimo.nl/richtlijnen/indicatiestelling-antibioticagebruik-in-de-mondzorg/therapeutisch-antibioticumgebruik-peri-implantitis/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · Richtlijn 2018 · richtlijnsamenvatting 4 en 5
https://www.hetkimo.nl/richtlijnen/peri-implantaire-mucositis-en-peri-implantitis/introductie/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
NVVC · Netherlands Heart Journal · Neth Heart J 2026;34(Suppl 1):S1–S13 · online 18 december 2025 · DOI 10.1007/s12471-025-02010-w
https://pure.umcutrecht.nl/ws/files/705565154/s12471-025-02010-w.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlands Huisartsen Genootschap · auteursversie via NVMKA · Versie 1.0 · november 2016 · oorspronkelijke tekst; huidige NHG-webrevisie niet verifieerbaar
https://www.nvmka.nl/wp-content/uploads/2022/07/2016-NHG-Behandelrichtlijn-Endocarditisprofylaxe-1.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO — Kennisinstituut Mondzorg · In werking 15 juni 2026 · PDF-tekst 28 maart 2025 · KNMT-aanvaarding 20 april 2026
https://www.hetkimo.nl/wp-content/uploads/2026/06/KPR-EMK-richtlijn-28032025.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/m/metronidazol__oraal_
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/a/amoxicilline_clavulaanzuur
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Zorginstituut Nederland — Farmacotherapeutisch Kompas · Dynamische preparaattekst · geen afzonderlijke revisiedatum vermeld
https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/c/ceftriaxon
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
European Academy of Paediatric Dentistry · 2025 · Eur Arch Paediatr Dent 26:1037–1043
https://link.springer.com/article/10.1007/s40368-025-01068-9
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlands Kenniscentrum Farmacotherapie bij Kinderen · Online monografie
https://www.kinderformularium.nl/geneesmiddel/7/amoxicilline
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlands Kenniscentrum Farmacotherapie bij Kinderen · Online monografie
https://www.kinderformularium.nl/geneesmiddel/312/clindamycine
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · RVG 117001 · 125 mg/5 mL en RVG 117002 · 250 mg/5 mL
https://www.geneesmiddeleninformatiebank.nl/smpc/h117003_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · RVG 06354 · 75 mg/5 mL
https://www.geneesmiddeleninformatiebank.nl/smpc/h06354_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
American Academy of Pediatrics · Pediatrics 135(4):784–787 · 2015
https://publications.aap.org/pediatrics/article/135/4/e20150072/33600/Metric-Units-and-the-Preferred-Dosing-of-Orally
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KNMG en beroepsorganisaties, waaronder KNMT · 2013 · Richtlijn Elektronisch voorschrijven
https://www.knmg.nl/download/richtlijn-elektronisch-voorschrijven-2
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · RVG 09840
https://www.geneesmiddeleninformatiebank.nl/smpc/h09840_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · RVG 134134 · 1 g, poeder voor oplossing voor injectie/infusie
https://www.geneesmiddeleninformatiebank.nl/smpc/h134135_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlandse Vereniging voor Mond-, Kaak- en Aangezichtschirurgie · 2024 · Bijlage 5
https://www.nvmka.nl/wp-content/uploads/2024-Bijlage_Spoedlijst_5__NVMKA_Nederlandse_Vereniging_voor_Mond-_Kaak-_en_Aangezichtschirurgie.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Centers for Disease Control and Prevention · CDC 2000 · documentatie 2024
https://www.cdc.gov/growth-chart-training/hcp/computer-programs/sas.html
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Johnson KB et al. · Pediatrics · 2011 · 128(2):e422–e428
https://pmc.ncbi.nlm.nih.gov/articles/PMC3387858/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
European Society of Cardiology · ESC 2023 · Essential messages
https://www.escardio.org/static-file/Escardio/Guidelines/Products/Slide%20sets/2023%20Gls/Essential%20Messages_2023%20Endocarditis.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Health Service Executive, Ierland · Versie 2.0 · lokale behandeling
https://assets.hse.ie/media/documents/Pericoronitis_guideline.pdf#page=1
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie · MKA-leidraad 1.3 · november 2025
https://www.nvmka.nl/wp-content/uploads/2025-Pericoronitis-MKA-leidraad-1.3.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie · MKA-leidraad 2.0 · november 2025
https://www.nvmka.nl/wp-content/uploads/2025-Alveolitis-MKA-leidraad-2.0.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlandse Orthopaedische Vereniging en Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde · Richtlijnmodule · 2016
https://richtlijnendatabase.nl/richtlijn/antibioticaprofylaxe_bij_gewrichtsprothese/antibioticaprofylaxe_bij_gewrichtsprothese.html
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Nederlandse Vereniging voor Endodontologie · Update 2025 · versie 1.0
https://nvve.com/wp-content/uploads/2026/08/Richtlijn-Endodontische-Diagnostiek-en-Behandeling-update-2025_v1.0.pdf#page=221
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO – Kennisinstituut Mondzorg · Nederlandse uitgave · 2025
https://www.hetkimo.nl/richtlijnen/dtg/over-de-dental-trauma-guide/
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde · Online praktijkrichtlijn
https://knmt.nl/praktijkzaken/regelen-rond-kwaliteit-en-klachten/opvang-tandheelkundige-spoedgevallen/beoordeling-van-spoed
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KNMT · Alles over het gebit · Online instructie voor eerste hulp bij tandletsel
https://www.allesoverhetgebit.nl/alles-over-mondgezondheid/aandoeningen/tand-eruit-tand-erin
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
KIMO – Kennisinstituut Mondzorg · Nederlandse instructie · 2025
https://www.hetkimo.nl/wp-content/uploads/2025/04/Spalkinstructie-KIMO-v2.pdf#page=3
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
International Association of Dental Traumatology · Dental Traumatology · 2020 · onderzoek, follow-up en tetanus
https://www.aapd.org/globalassets/media/policies_guidelines/e_avulsion.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
European Society of Cardiology · 2023 · European Heart Journal 44:3948–4042 · tabel 6
https://academic.oup.com/eurheartj/article/44/39/3948/7243107
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 14999
https://www.geneesmiddeleninformatiebank.nl/smpc/h14999_smpc.pdf
Sources · Version 0.3.6 · Bijgewerkt 2026-11-11
Antibiotic treatment and prophylaxis in dental care, with dosing regimens for adults and children and information on risk groups and medicines.
Assess the indication, age and patient-specific risks before choosing a regimen. Weight-based calculation applies only to the selected paediatric regimen. Use the relevant product information to check allergies, renal and hepatic function, interactions, pregnancy and breastfeeding.
College ter Beoordeling van Geneesmiddelen · SmPC · RVG 30849–30850
https://www.geneesmiddeleninformatiebank.nl/smpc/h30849_smpc.pdf
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