COX-2 inhibitors
Celecoxib and etoricoxib · specific indications.
Prescription optionsCheck the indication by product
These medicines have different authorised indications. The general NHG pain guidance prefers conventional NSAIDs to COX-2 inhibitors. Before use, check the product-specific indication and cardiovascular contraindications.
Prescription options
Draft for your prescribing system. Check patient details, contraindications and medication safety before prescribing.
Etoricoxib following dental surgery
An authorised option for moderate pain after a dental procedure moderate pain after dental surgery in suitable adults with normal hepatic function. The general pain policy prefers classic NSAIDs.
Checks before prescribing
Do not use in NYHA class II–IV heart failure, estimated creatinine clearance below 30 mL/min, persistent uncontrolled blood pressure above 140/90 mmHg, or established arterial vascular disease. Etoricoxib is also contraindicated during pregnancy or breastfeeding. See the complete contraindications in SmPC §4.3. KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal risk, hypersensitivity and interactions. Don't combine two NSAIDs.
R/ Etoricoxib 90 mg film-coated tablet
- Per dose
- 90 mg by mouth (1 tablet)
- Frequency and interval in this example
- Once daily, about 24 hours between doses
- Maximum per 24 hours
- 90 mg (1 tablet)
- Quantity in this draft
- Maximum 3 tablets
Maximum duration of use: 3 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- CBG · Arcoxia 90 mg, filmomhulde tabletten · RVG 27706 · SmPC §4.1–4.5, pijn na tandheelkundige ingrepen
- Farmacotherapeutisch Kompas · Etoricoxib · Advies, dosering na tandheelkundige ingrepen en contra-indicaties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
