When taking antithrombotics
Pain relief after a procedure that causes bleeding.
Prescription optionsScope
The recommendation applies to patients who take antithrombotics and have undergone a dental procedure that causes bleeding. It also applies if antithrombotic therapy was temporarily interrupted before the procedure.
Pain relief after a procedure that causes bleeding
If needed, choose paracetamol if appropriate for the patient. Check patient-specific precautions and include paracetamol from all medicines. Use Extraction & antithrombotics for management around the procedure.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
With repeated use alongside a vitamin K antagonist, check the interaction with paracetamol.
Paracetamol aloneAfter a procedure that causes bleeding, if paracetamol is suitable
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
