Paracetamol
First choice in acute nociceptive pain.
Prescription optionsRole in treatment
The Farmacotherapeutisch Kompas lists paracetamol as first choice in acute nociceptive pain.
Lower daily limit when risk factors are present
The Farmacotherapeutisch Kompas cites the following maximum doses from the NHG pain guideline: 3,000 mg without risk factors, 2,000 mg with one and 1,500 mg with two or more per day. A lower limit may apply depending on the product or patient. See Frailty, kidney or liver impairment.
Check for interactions
With repeated use alongside a vitamin K antagonist, check the interaction in the product monograph. If there are risk factors for hepatotoxicity, assess the dose and duration separately.
Prescription options
Draft for your prescribing system. Check patient details, contraindications and medication safety before prescribing.
Paracetamol alone
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
If relief is inadequate, consider only a combination that is appropriate for the clinical situation and patient.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
