Pain relief guidance
Choosing pain relief for acute dental pain and pain after treatment.
Start with the cause
Assess and treat the dental cause. If temporary pain relief is appropriate, paracetamol alone is the first option.
Check what has already been taken and which risk factors affect the daily limit.
When to combine medicines
If paracetamol provides insufficient relief, one suitable NSAID may be added. Check renal function, gastrointestinal and cardiovascular risk, interactions, and whether the patient already uses an NSAID.
Two separate medicines allow independent dosing. A fixed-dose combination is an alternative if the strength and ratio are appropriate. Check over-the-counter medicines first to avoid duplicate dosing.
After a procedure or if pain persists
After a simple extraction, use non-opioid pain relief. Reassess if pain persists or worsens, including wound, swelling and bleeding.
For severe acute pain, after that assessment, tramadol may sometimes be considered if non-opioid treatment is insufficient.
When to adjust the standard regimen
For children, pregnancy or breastfeeding and frailty use the corresponding guidance.
Sources for this guidance
Reference for dentists on acute dental pain and pain after treatment.
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- ADA Science & Research Institute en partners · Pharmacologic management of acute dental pain in adolescents, adults, and older adults · JADA 2024 · tabel 1, eenvoudige en chirurgische extracties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- KNMT · Opvang tandheelkundige spoedgevallen buiten reguliere openingstijden · Beoordeling van spoed · termijn bij nabloeding, pijn en kinderen
- Kinderformularium · Paracetamol · Doseeradviezen per leeftijd, gewicht, indicatie en toedieningsweg
- Moeders van Morgen Lareb · De behandeling van acute pijn tijdens de zwangerschap · Paracetamol, NSAID’s en overleg bij andere pijnstillers
