Persistent or worsening pain
Reassess if relief is inadequate or the clinical course changes.
Prescription optionsReassess before increasing the dose
Check the diagnosis, how the pain has changed and which medicines the patient has actually taken before changing the regimen. New swelling, fever, difficulty swallowing or bleeding requires a separate assessment.
Pain relief after reassessment
For acute nociceptive pain without complications, where appropriate initial analgesia has not yet been used, paracetamol is a first option. In adults with insufficient relief despite appropriate use, adding ibuprofen may be appropriate if an NSAID is appropriate for both the patient and the confirmed cause.
Next step
For pain after treatment, follow the pathway for After root canal treatment or After extraction. For telephone advice about deferring care, follow Outside opening hours.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
Paracetamol aloneAfter reassessment of uncomplicated acute pain when suitable initial analgesia is still lacking
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Paracetamol with ibuprofenFor confirmed toothache with inadequate relief from paracetamol, if an NSAID is suitable
For adults weighing over 55 kg without risk factors for hepatotoxicity, if paracetamol alone does not give adequate relief and an NSAID is appropriate. Both medicines can be taken at the same time. Track the dosing interval and daily maximum separately for each.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Count paracetamol from all products.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
R/ Ibuprofen 400 mg film-coated tablet (Spidifen)
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Spidifen SmPC §4.2: every 4 to 6 hours if necessary.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- KNMT · Opvang tandheelkundige spoedgevallen buiten reguliere openingstijden · Beoordeling van spoed · termijn bij nabloeding, pijn en kinderen
- UMC Utrecht · Poliklinische ingrepen in de mond · Pijn, zwelling, nabloeding en wanneer contact opnemen
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- CBG · Spidifen 400 mg, tabletten · RVG 25385 · SmPC §4.1–4.5
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
