After root canal treatment
Expected postoperative pain and reassessment.
Prescription optionsPost-treatment pain relief
For mild, expected pain after treatment, paracetamol may be sufficient. If substantial postoperative pain is expected, the NVvE prefers paracetamol with an NSAID. In adults, consider paracetamol with ibuprofen if ibuprofen is appropriate. If an NSAID is contraindicated, choose paracetamol alone if suitable.
Reassessment
Unexpected or increasing pain requires reassessment of the cause. After extraction, follow the pathway for After extraction.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
Paracetamol aloneFor mild postoperative pain or when an NSAID is unsuitable
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Paracetamol with ibuprofen after a procedureWhen substantial postoperative pain is expected and an NSAID is suitable
For adults weighing more than 55 kg without risk factors for hepatotoxicity when both medicines are indicated after the dental procedure. Track each medicine's dosing interval and maximum daily dose separately.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Do not use Ibuprofen RIA in patients with active bleeding, a bleeding diathesis or receiving anticoagulant treatment. Full contraindications in the SmPC. Count paracetamol from all products.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
R/ Ibuprofen 400 mg RIA film-coated tablet
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Ibuprofen RIA SmPC §4.2: repeat every 4 to 6 hours, up to 3 tablets of 400 mg daily.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- ADA Science & Research Institute en partners · Pharmacologic management of acute dental pain in adolescents, adults, and older adults · JADA 2024 · tabel 1, eenvoudige en chirurgische extracties
- CBG · Ibuprofen 400 mg RIA, filmomhulde tabletten · RVG 23734 · SmPC §4.1–4.5, pijn na tandheelkundige ingrepen, dosering en voorzorgen
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- SDCEP · Management of acute dental problems · Analgesia · Paracetamol, ibuprofen en vermijden van aspirine of ibuprofen bij bloeding
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
