After extraction
Pain after a simple or surgical extraction.
Prescription optionsPain relief after extraction
For adults with pain after a simple or surgical extraction, ibuprofen is a first option according to the ADA if an NSAID is appropriate. If needed, paracetamol can be added. If an NSAID is unsuitable, choose paracetamol alone where appropriate.
The ADA advises against opioids after a simple extraction. For patients taking antithrombotics, follow the KIMO advice above.
In case of abnormal course
Assess worsening pain, persistent bleeding and signs of infection. See Dry socket, Postoperative bleeding or Swelling and infection.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
Ibuprofen 400 mg RIAFor pain after treatment, if an NSAID is suitable
Short-term example for adults with pain after a dental procedure or acute muscle or joint pain, when an NSAID is suitable.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Do not use Ibuprofen RIA in patients with active bleeding, a bleeding diathesis or receiving anticoagulant treatment. Full contraindications in the SmPC.
R/ Ibuprofen 400 mg RIA film-coated tablet
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Ibuprofen RIA SmPC §4.2: repeat every 4 to 6 hours, up to 3 tablets of 400 mg daily.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Paracetamol with ibuprofen after a procedureIf paracetamol is needed in addition to ibuprofen
For adults weighing more than 55 kg without risk factors for hepatotoxicity when both medicines are indicated after the dental procedure. Track each medicine's dosing interval and maximum daily dose separately.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Do not use Ibuprofen RIA in patients with active bleeding, a bleeding diathesis or receiving anticoagulant treatment. Full contraindications in the SmPC. Count paracetamol from all products.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
R/ Ibuprofen 400 mg RIA film-coated tablet
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Ibuprofen RIA SmPC §4.2: repeat every 4 to 6 hours, up to 3 tablets of 400 mg daily.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Paracetamol aloneIf an NSAID is unsuitable
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Ibuprofen 600 mg · sachet after third molar surgerySingle-dose example after surgical removal of a third molar
Single-dose example for pain after surgical removal of a third molar in a suitable adult. For ordinary toothache, the product information lists 400 mg per dose.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Check any ibuprofen already taken and the sodium and sucrose content of this sachet.
R/ Brufen Bruis 600 mg, effervescent granules per sachet
- Per dose
- 600 mg by mouth (1 sachet). Stir into a glass of water and drink all of the solution.
- Frequency and interval in this example
- Single dose. Reassess if further pain relief is needed.
- Maximum per 24 hours
- 600 mg (1 sachet) in this example
- Quantity in this draft
- Maximum 1 sachet
Duration in this example: 1 day. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- ADA Science & Research Institute en partners · Pharmacologic management of acute dental pain in adolescents, adults, and older adults · JADA 2024 · tabel 1, eenvoudige en chirurgische extracties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- UMC Utrecht · Poliklinische ingrepen in de mond · Pijn, zwelling, nabloeding en wanneer contact opnemen
- CBG · Ibuprofen 400 mg RIA, filmomhulde tabletten · RVG 23734 · SmPC §4.1–4.5, pijn na tandheelkundige ingrepen, dosering en voorzorgen
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- SDCEP · Management of acute dental problems · Analgesia · Paracetamol, ibuprofen en vermijden van aspirine of ibuprofen bij bloeding
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- CBG · Brufen Bruis 600 mg, bruisgranulaat in sachets · RVG 13331 · SmPC §4.1–4.4, tandheelkundige indicaties en toediening
- Seymour et al. · British Journal of Oral and Maxillofacial Surgery · Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain · 1996 · eenmalige giften na chirurgische verwijdering van derde molaren
- Farmacotherapeutisch Kompas · Ibuprofen (systemisch) · Contra-indicaties, interacties en zwangerschap
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
