Dry socket
Severe pain again a few days after extraction.
Prescription optionsInspect the extraction wound
Severe pain that develops or returns a few days after extraction may indicate alveolitis. Assess the wound urgently and look for signs of another complication, such as spreading swelling or fever.
Local aftercare
Consider local irrigation with normal saline. See also After extraction.
Pain relief in addition to wound care
Check which analgesics the patient has already taken. For temporary relief in adults, ibuprofen can be used if there is no active bleeding and an NSAID is appropriate. Otherwise, if needed, choose paracetamol where appropriate.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
Ibuprofen 400 mg RIAAlongside wound care, if there is no active bleeding and an NSAID is suitable
Short-term example for adults with pain after a dental procedure or acute muscle or joint pain, when an NSAID is suitable.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Do not use Ibuprofen RIA in patients with active bleeding, a bleeding diathesis or receiving anticoagulant treatment. Full contraindications in the SmPC.
R/ Ibuprofen 400 mg RIA film-coated tablet
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Ibuprofen RIA SmPC §4.2: repeat every 4 to 6 hours, up to 3 tablets of 400 mg daily.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Paracetamol aloneAlongside wound care if an NSAID is unsuitable
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- KIMO · Derde molaar · Klinische praktijkrichtlijn · uitgangsvraag 5, nazorg
- NHS inform · Wisdom tooth removal · Complications · dry socket
- UMC Utrecht · Poliklinische ingrepen in de mond · Pijn, zwelling, nabloeding en wanneer contact opnemen
- SDCEP · Alveolar osteitis (dry socket) · Initial management en subsequent care · urgente beoordeling, pijnstilling en lokale nazorg
- SDCEP · Management of acute dental problems · Analgesia · Paracetamol, ibuprofen en vermijden van aspirine of ibuprofen bij bloeding
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- CBG · Ibuprofen 400 mg RIA, filmomhulde tabletten · RVG 23734 · SmPC §4.1–4.5, pijn na tandheelkundige ingrepen, dosering en voorzorgen
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
