Naproxen
Systemic NSAID.
Prescription optionsRole in treatment
Naproxen is an NSAID option for acute nociceptive pain when the clinical situation and patient factors allow. Check the formulation and current product monograph.
Pre-use check
Check gastrointestinal, renal and cardiovascular risk, hypersensitivity and interactions. Ask about over-the-counter medicines. Do not combine two systemic NSAIDs.
Prescription options
Draft for your prescribing system. Check patient details, contraindications and medication safety before prescribing.
Naproxen after extraction
Example for an adult with pain and swelling after extraction when an NSAID is appropriate. This example uses a 12-hour interval; the product information allows 8–12 hours.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment.
R/ Naproxen 250 mg tablet
- Per dose
- Initial single dose of 500 mg by mouth (2 tablets), then 250 mg (1 tablet) per dose
- Frequency and interval in this example
- Repeat after 12 hours if necessary and then every 12 hours
- Maximum per 24 hours
- In this example 750 mg in the first 24 hours, then 500 mg per 24 hours
- Quantity in this draft
- Maximum 5 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- Farmacotherapeutisch Kompas · Naproxen · Contra-indicaties, interacties en waarschuwingen
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- CBG · Naproxen 250 mg Teva · RVG 12570 · SmPC §4.1–4.5, postoperatieve pijn en zwelling
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
