Fixed combinationsContains opioids
Paracetamol / codeine
Not recommended in acute endodontic pain.
Registered combination
There is a registered tablet containing 500 mg paracetamol and 30 mg codeine phosphate. The NVvE advises against this combination in acute pain due to irreversible pulpitis or symptomatic apical periodontitis.
Medication review
Check for duplicate paracetamol, other opioids and sedating medicines. Relevant concerns with codeine include sedation, respiratory depression and variation in CYP2D6 metabolism. See Acute toothache for the recommended options.
Prescription options
The NVvE advises against this combination preparation for acute endodontic pain. If needed, select a suitable non-opioid regimen for this situation.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- Farmacotherapeutisch Kompas · Paracetamol/codeïne · Advies, interacties en contra-indicaties
- CBG · Paracetamol/Codeïne Eurogenerics 500 mg/30 mg · RVG 131517 · productregistratie en SmPC