Pain in the jaw and face
If examination does not identify a clear dental cause.
Prescription optionsWiden the differential diagnosis
If pain is unexplained, assess the masticatory muscles and temporomandibular joint as well. Brief attacks of shooting pain may indicate neuropathic pain. If the cause remains unclear, consider appropriate medical referral or referral to an orofacial pain specialist.
Pain relief for acute TMD
For confirmed acute pain from the masticatory muscles or temporomandibular joint, paracetamol can be used briefly alongside measures to rest the jaw. In adults, ibuprofen may be an option if an NSAID is appropriate.
On suspicion of neuropathic pain
If neuropathic pain is suspected, follow a diagnosis-specific care pathway. The guideline advises against opioids in trigeminal neuralgia.
Prescription options
Drafts for adults. Check the indication, contraindications and current medicines before prescribing.
Paracetamol aloneShort-term use for confirmed acute masticatory muscle or temporomandibular joint pain
First option for acute nociceptive pain. This example applies to adults weighing more than 55 kg without risk factors for hepatotoxicity.
Checks before prescribing
Include all paracetamol from over-the-counter and combination products. Adjust the dose if there are risk factors.
R/ Paracetamol 500 mg tablet
- Per dose
- 1,000 mg by mouth (2 tablets)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Maximum per 24 hours
- 3,000 mg (6 tablets)
- Quantity in this draft
- Maximum 12 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Ibuprofen 400 mg RIAFor confirmed acute TMD, if an NSAID is suitable
Short-term example for adults with pain after a dental procedure or acute muscle or joint pain, when an NSAID is suitable.
Checks before prescribing
KIMO advises against NSAID use after a dental procedure that causes bleeding in patients taking antithrombotics, even if antithrombotic therapy has been temporarily interrupted. Discuss over-the-counter NSAIDs as well. See When taking antithrombotics. Check gastrointestinal, renal and cardiovascular risk factors, pregnancy, hypersensitivity and interactions. Do not combine two NSAIDs. See Frailty, kidney or liver impairment. Do not use Ibuprofen RIA in patients with active bleeding, a bleeding diathesis or receiving anticoagulant treatment. Full contraindications in the SmPC.
R/ Ibuprofen 400 mg RIA film-coated tablet
- Per dose
- 400 mg by mouth (1 tablet)
- Frequency and interval in this example
- If necessary up to 3 times a day, approximately 8 hours between intakes
- Ibuprofen RIA SmPC §4.2: repeat every 4 to 6 hours, up to 3 tablets of 400 mg daily.
- Maximum per 24 hours
- 1,200 mg (3 tablets)
- Quantity in this draft
- Maximum 6 tablets
Duration in this example: 2 days. Stop earlier if the medicine is no longer needed. Reassess if pain relief is inadequate or pain worsens.
Sources for this topic
Reference for dentists on acute dental pain and pain after treatment.
- NHG en betrokken beroepsverenigingen · Chronische aangezichtspijn · Differentiaaldiagnose, waaronder TMD en trigeminusneuralgie
- SDCEP · Acute temporomandibular disorder · Initial management · pijnstilling en zelfzorg bij acute TMD
- SDCEP · Management of acute dental problems · Analgesia · Paracetamol, ibuprofen en vermijden van aspirine of ibuprofen bij bloeding
- Farmacotherapeutisch Kompas · Pijn · Advies en stappenplan bij acute nociceptieve pijn
- NVvE · Richtlijn endodontische diagnostiek en behandeling · Update 2025 v1.0 · hoofdstuk 9, p. 219–222
- Farmacotherapeutisch Kompas · Paracetamol · Doseringen, interacties en waarschuwingen
- CBG · Paracetamol PharmaMatch 500 mg · RVG 109490 · SmPC §4.2–4.5
- CBG · Ibuprofen 400 mg RIA, filmomhulde tabletten · RVG 23734 · SmPC §4.1–4.5, pijn na tandheelkundige ingrepen, dosering en voorzorgen
- Farmacotherapeutisch Kompas · NSAID’s, systemisch · Typerende bijwerkingen, toepasbaarheid en interacties
- KIMO · Bloedige ingrepen in de mondzorg bij patiënten die antitrombotica gebruiken · Versie 2025 · uitgangsvraag 5, NSAID-beleid
- KNMG en betrokken beroepsverenigingen · Elektronisch voorschrijven · Artikelen 2 en 3 · medicatiebewaking
